Acute Superior Mesenteric Artery Embolism Secondary to Left Ventricular Thrombus in a Young Male with Ischemic Cardiomyopathy: A Case Report
Keywords:
Acute mesenteric ischemia; Superior mesenteric artery embolism; Left ventricular thrombus; Ischemic cardiomyopathy; Cardioembolism; Exploratory laparotomy.Abstract
Introduction: Acute mesenteric ischemia (AMI) is a rare but life-threatening vascular emergency associated with high mortality due to delayed diagnosis and rapid progression to bowel infarction. Superior mesenteric artery (SMA) embolism secondary to left ventricular (LV) thrombus is an uncommon cause, particularly in young adults.
Aim & Objective: To highlight an uncommon case of AMI caused by SMA embolism secondary to LV thrombus in a young patient with ischemic cardiomyopathy and emphasize the importance of early diagnosis and prompt surgical intervention.
Case Presentation: A 31-year-old male with ischemic cardiomyopathy, previous anteroseptal myocardial infarction, severe LV systolic dysfunction (ejection fraction 35%), and documented LV thrombus presented with severe diffuse abdominal pain, distension, and obstipation for three days. Examination revealed generalized peritonitis. Investigations showed marked leukocytosis (22.46 × 10³/µL) with mildly elevated serum lactate (2.2 mmol/L). Echocardiography demonstrated a large LV thrombus measuring 4.5 × 0.9 cm. Contrast-enhanced CT revealed complete SMA occlusion, small bowel ischemia, chronic celiac trunk occlusion, and splenic infarction, suggesting systemic thromboembolism. Emergency laparotomy revealed approximately 30 cm of gangrenous jejunoileal bowel, which was resected with double-barrel stoma formation. Histopathology confirmed transmural ischemic necrosis with hemorrhagic congestion. Postoperatively, an enterocutaneous fistula developed and was managed conservatively with nutritional support and wound care.
Result: The patient recovered and was discharged in a hemodynamically stable condition on guideline-directed heart failure therapy and long-term anticoagulation.
Conclusion: LV thrombus is an uncommon but important cause of acute SMA embolism in young patients with ischemic cardiomyopathy. Mildly elevated serum lactate does not exclude advanced bowel ischemia. Early CTA, prompt surgical intervention, and multidisciplinary management are essential for improving outcomes in patients with acute mesenteric ischemia.
REFERENCES
- Clair DG, Beach JM. Mesenteric ischemia. N Engl J Med. 2016;374(10):959-968.
- Bala M, Catena F, Kashuk J, De Simone B, Gomes CA, Weber D, et al. Acute mesenteric ischemia: updated guidelines of the World Society of Emergency Surgery. World J Emerg Surg. 2022;17(1):1-17. https://doi.org/10.1186/s13017-017-0150-5
- Oldenburg WA, Lau LL, Rodenberg TJ, Edmonds HJ, Burger CD. Acute mesenteric ischemia: a clinical review. Arch Intern Med. 2004;164(10):1054-1062. https://doi.org/10.1001/archinte.164.10.1054
- Acosta S, Björck M. Modern treatment of acute mesenteric ischaemia. Br J Surg. 2014;101(1):100-108. https://doi.org/10.1002/bjs.9330
- Kärkkäinen JM, Lehtimäki TT, Manninen H, Paajanen H. Acute mesenteric ischemia is a more common cause than expected of acute abdomen in the elderly. J Gastrointest Surg. 2015;19(8):1407-1414. https://doi.org/10.1007/s11605-015-2830-3
- Tilsed JV, Casamassima A, Kurihara H, Mariani D, Martínez I, Pereira J, et al. ESTES guidelines: acute mesenteric ischaemia. Eur J Trauma Emerg Surg. 2016;42(2):253-270. https://doi.org/10.1007/s00068-016-0634-0
- Endean ED, Barnes SL, Kwolek CJ, Minion DJ, Schwarcz TH, Mentzer RM Jr. Surgical management of thrombotic acute intestinal ischemia. Ann Surg. 2001;233(6):801-808. https://doi.org/10.1097/00000658-200106000-00010
- Steele SR. Ischemic colitis complicating major vascular surgery. Surg Clin North Am. 2007;87(5):1099-1114. https://doi.org/10.1016/j.suc.2007.07.007
- Park WM, Gloviczki P, Cherry KJ Jr, Hallett JW Jr, Bower TC, Panneton JM, et al. Contemporary management of acute mesenteric ischemia: factors associated with survival. J Vasc Surg. 2002;35(3):445-452. https://doi.org/10.1067/mva.2002.120373
- Eltarawy IG, Etman YM, Zenati M, Simmons RL, Rosengart MR. Acute mesenteric ischemia: the importance of early surgical consultation. Am Surg. 2009;75(3):212-219. https://doi.org/10.1177/000313480907500305

