RELATIONSHIP BETWEEN WHITE BLOOD CELL (WBC) COUNTAND C-REACTIVE PROTEIN (CRP) WITH ANGIOGRAPHICSEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITHACUTE CORONARY SYNDROME

Abstract

Background: Inflammation plays an important role in the initiation and progression of atherosclerosis and systemic blood
markers of inflammation like white blood cell count and C-reactive protein have emerged as powerful predictor of coronary
events. This study was carried out to evaluate the relationship between baseline white blood cell count and C-reactive
protein with angiographic severity of coronary artery disease in patients with acute coronary syndrome and to identify those
subsets of patients with acute coronary syndrome who may need to undergo invasive strategy.
Method: A total of 100 patients with acute coronary syndrome including unstable angina, non-ST elevation myocardial
infarction and ST elevation myocardial infarction (not thrombolysed ) were evaluated in Department of Cardiology, Sawai
Man Singh Medical College & Hospital, Jaipur , Rajasthan, India with a aim to correlate baseline white blood cell count
and C-reactive protein with angiographic severity of coronary artery disease.
Results: This study observed that raised white blood cell count and raised C-reactive protein independently and
combination of both raised white blood cell count and CRP were significantly associated with angiographic more severe
coronary artery disease in form of multi vessel disease ,high stenosis score, more complex lesions and reduced TIMI flow
grading.
Conclusion: Raised white blood cell count and C- recactive protein in patient with acute coronary syndrome are associated
with angiographic features of severe coronary artery disease. Both these markers can be used as a simpler tool for risk
stratification patients with acute coronary syndrome.