THE CORRELATION OF MATERNAL INTERLEUKIN 4 ANDINDICATORS OF MODERATE AND SEVERE PREECLAMPSIA

Abstract

Aim
The purpose of this research is to study the formation of anti-inflammatory IL-4 cytokine and some indicators of moderate and
severe preeclampsia, and normotensive pregnancies in the third trimester of pregnancy
Material and methods
This is a single center study of 100 women with third trimester pregnancies. All patients gave their informed consent prior to
inclusion in the study.Patients were divided into two groups: 50 women with pregnancies complicated by varying degrees of
preeclampsia and control group of 50 normotensive pregnancies.
Cytokine levels in the serum were measured by the "sandwich" method of solid-phase enzyme immunoassay using double
antibody.
Statistical data processing was done using the SPSS13.0 software for Windows. Logistic regression analysis (Binary Logistic
Regression) was used to determine the predictive role of the parameters analyzed in the occurrence of severe preeclampsia.
Results
The obtained values of Pearson- coefficients’ linear correlation (r) indicate that IL-4 negatively correlates with LDH, creatinine,
uric acid and proteinuria, and positively correlates with number of blood platelets. IL-4 in severe preeclampsia has a downward
trend, between 28-40 weeks of gestation it may be considered a prognostic marker for the development of severe preeclampsia