COMPARISON OF PLASMA PROTEINS IN TYPE 2 DIABETES MELLITUS AND NON-DIABETICS

Abstract

Introduction: Insulin resistance in type 2 diabetes mellitus is known to alter fractional synthetic rates of different plasma proteins. Objective of the study was to compare plasma total proteins and albumin in type 2 diabetics with that of non-diabetic controls.
Methodology: This retrospective study was conducted in Adarsha Superspeciality Hospital, Udupi, Karnataka. Data of plasma proteins and demographic profiles of 173 type 2 diabetes mellitus patients was compared with that of 121 healthy non-diabetics. Mann Whitney U test was used to compare the data.
Results: A significantly low albumin (p= 0.0080) , significantly high globulin levels (p = 0.0246) were observed in type 2 DM. However differences in total protein levels were insignificant. Albumin/globulin ratio was found to be low very significantly (p=0.0006) in patients.
Conclusion: We conclude that hypoalbuminemia and hyper gamma globulinemia were observed in patients of type 2 DM as compared to non-diabetics